MALARIA RESEARCH CENTRE

PUBLICATIONS (Since 1999)

  1. Raja, T.N., Hu, T.H., Kadir, K.A., Mohamad, D.S.A. Divis, P.C.S. Wong, L.L., Hii, K-C & Singh, B. (2020) Naturally acquired human Plasmodium cynomolgi and Plasmodium knowlesi infections, Malaysian Borneo. Emerging Infectious Diseases, 26: 1801-1809.
  2. Hocking, S.E., Divis, P.C.S, Kadir, K.A., Singh, B. & Conway, D.J. (2020) Population genomic structure and recent evolution of Plasmodium knowlesi, Peninsular Malaysia. Emerging Infectious Diseases, 26: 1749-1758..
  3. Divis, P.C.S, Hu, T.H., Kadir, K.A., Mohammad, D.S.A., Hii, K.C., Daneshvar, C., Conway, D.J. & Singh, B. (2020) Efficient surveillance of Plasmodium knowlesi genetic subpopulations, Malaysian Borneo, 2000–2018. Emerging Infectious Diseases, 26: 1392-1398.
  4. Muller-Sienerth, N., Shilts, J. Kadir, K.A., Yman, V., Homann, M.V., Asghar, M., Ngasala, B., Singh, B., Farnert, A. & Wright, G.J. (2020) A panel of recombinant proteins from human-infective Plasmodium species for serological surveillance. Malaria Journal, 19; 31.
  1. Gamalo, L.F., Dimalibot, J., Kadir, K.A., Singh, B. & Paller, V.G (2019) Plasmodium knowlesi and other malaria parasites in long-tailed macaques from the Philippines. Malaria Journal, 18: 147.
  2. Feachem, R.G.A., Chen, I., Akbari, O., Bertozzi-Villa, A., Bhatt, S., Binka, F., Boni, M.F., Buckee, C., Dieleman, J., Dondorp, A., Eapen, A., Feachem N.S., Filler, S., Gething, P., Gosling, R., Haakenstad, A., Harvard, K., Hatefi, A., Jamison, D., Jones, K.E., Karema, C., Kamwi, R.N., Lal, A., Larson, E., Lees, M., Lobo, N.F., Micah, A.E., Moonen, B., Newby, G., Ning, X., Pate, M., Quiñones, M., Roh, M., Rolfe, B., Shanks, D., Singh, B., Staley, K., Tulloch, J., Wegbreit, J., Woo, H.J. & Mpanju-Shumbusho, W. (2019) Malaria eradication withing a generation: ambitious, achievable, and necessary. The Lancet, 394 (10203), 1056-1112.
  1. Raja, T. N., Lee, K. S., Zainudin, R., Perkins, S., & Singh, B. (2018) Malaria parasites of long-tailed macaques in Sarawak, Malaysian Borneo: a novel species and demographic and evolutionary histories. BMC Evolutionary Biology, 18:49.
  2. Divis, P.C.S., Duffy, C.W., Kadir, K.A., Singh, B. & Conway, D.J. (2018) Genome-wide mosaicism in divergence between zoonotic malaria parasite subpopulations with separate sympatric transmission cycles. Molecular Ecology, 27:860-870.
  3. Chang, C.Y., Pui, W.C., Kadir, K.A. & Singh, B. (2018) Spontaneous splenic rupture in , Plasmodium knowlesi malaria. Malaria Journal17: 448.
  1. Siner, A., Tze, L.S., Kadir, K.A., Mohamad, D.S.A., Thomas, F.K., Narihan, M.Z. A. & Singh, B. (2017) Absence of Plasmodium inui and Plasmodium cynomolgi, but detection of Plasmodium knowlesi and Plasmodium vivax infections in asymptomatic humans in the Betong division of Sarawak, Malaysian Borneo. Malaria Journal. 16: 417.
  2. Divis, P.C.S., Lin, L., Rovie-Ryan, J.J., Kadir, K.A., Anderios, F., Hisam, S., Sharma, R.S.K., Singh, B. & Conway, D.J. (2017) Three major divergent subpopulations of the malaria parasite Plasmodium knowlesi. Emerging Infectious Diseases, 23(4):616-624.
  3. Zhang, X., Meng, Y., Houghton, P., Liu, M., Kanthaswamy, S., Oldt, R., Ng, J., Trask, J.S., Huang, R., Singh, B., Du, H. & Smith, D.G. (2017) Ancestry, Plasmodium cynomolgi prevalence and rhesus macaque admixture in cynomolgus macaques (Macaca fascicularis) bred for export in Chinese breeding farms. Journal of Medical Primatology. 46(2): 31-41.
  1. Zhang, X., Kadir, K.A., Quintanilla-Zariñan, L.F., Villano, J., Houghton, P., Du, H., Singh, B. & Smith, D.S. (2016) Distribution and prevalence of malaria parasites among long-tailed macaques (Macaca fascicularis) in regional populations across Southeast Asia. Malaria Journal, 15:450.
  2. Shearer, F.M., Huang, Z., Weiss, D.J., Wiebe, A., Gibson, H.S., Battle, K.E., Pigott, D.M., Brady, O.J., Putaporntip, C., Jongwutiwes, S., Lau, Y.L., Manske, M., Amato, R., Elyazar, I.R.F., Vythilingam, I., Bhatt, S., Gething, P.W., Singh, B., Golding, N., Hay, S.I. & Moyes, C.L. (2016) Estimating geographical variation in the risk of zoonotic Plasmodium knowlesi infection in countries eliminating malaria. PLoS Neglected Tropical Diseases , 10(8): e0004915.
  3. Sutton, P.L., Luo, Z, Divis, P.C.S., Friedrich, V.K., Barnwell, J., Conway, D.J., Singh, B., Sullivan, S.A. & Carlton, J.M. (2016) Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi . Infection, Genetics and Evolution. 40: 243-252
  1. Assefa, S., Lim, C., Preston, M.D., Duffy, C.W., Nair, M.B., Adroub, S.A., Kadir, K.A., Goldberg, J.M., Neafsey, D.E., Divis, P.C.S., Clark, T.G., Duraisingh, M.T., Conway, D.J., Pain, A. & Singh, B. (2015) Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi . Proceedings of the National Academy of Sciences USA. 112 (42): 13027-13032.
  2. Divis, P.C.S., Singh, B., Anderios, F., Hasim, S., Assefa, S., Duffy, C.W. & Conway, D.J. (2015) Admixture in humans of two divergent Plasmodium knowlesi populations associated with different macaque host species. PLoS Pathogens,11(5): e1004888.
  3. Faber, B.W., Abdul Kadir, K., Rodriguez-Garcia, R., Remarque, E.J., Saul, F.A., Normand, B.V-L., Bentley, G., Kocken, C.H.M. & Singh, B. (2015) Low levels of polymorphisms and no evidence for diversifying selection on the Plasmodium knowlesi Apical Membrane Antigen 1 Gene. PLoS ONE, 10(4):e0124400.
  4. Normand, B.V-L, Faber, B.W., Saul, F.A., Eijk, M., Thomas, A.W., Singh, B., Kocken, C.H.M. & Bentley, G.A. (2015) Crystal structure of Plasmodium knowlesi Apical Membrane Antigen 1 and its complex with an invasion-inhibitory monoclonal antibody. PLoS ONE, 10(4):e0123567.
  1. Ahmed, M.A., Pinheiro, M.M., Divis, P.C., Siner, A., Zainudin, R., Wong, I.T., Lu, C.W., Singh-Khaira, S.K., Millar, S.B., Lynch, S., Willmann, M., Singh, B., Krishna, S. & Cox-Singh, J. (2014) Disease progression in Plasmodium knowlesi malaria is linked to variation in invasion gene families. PLoS Neglected Tropical Diseases, 8(8): e3086.
  2. Moyes, C.L., Henry, A.J., Golding, N., Huang, Z., Singh, B., Baird, K.J., Newton, Huffman, M., Duda, K.A., Drakeley, C.J., Elyazar, I.R.F., Anstey, N.M., Chen, Q., Zommers, Z., Bhatt, S., Gething, P.W. & Hay, S.I. (2014) Defining the geographical range of the Plasmodium knowlesi reservoir. PLoS Neglected Tropical Diseases, 8(3): e2780.
  3. Foster, D., Cox-Singh, J., Mohamad, S.A.D., Krishna, S., Chin, P.P. & Singh, B. (2014) Evaluation of three rapid diagnostic tests for the detection of human infections with Plasmodium knowlesi. Malaria Journal, 13, 60.
  1. Fatih, F.A., Staines, H.M., Siner, A., Ahmed, M.A., Woon, L.C., Pasini, E.M., Kocken, C.H.M., Singh, B., Cox-Singh, J. & Krishna, S. (2013) Susceptibility of human Plasmodium knowlesi infections to anti-malarials. Malaria Journal, 12, 425.
  2. Singh, B. & Daneshvar, C. (2013) Human infections and detection of Plasmodium knowlesi. Clinical Microbiology Reviews, 26, 165-184.
  1. Willmann, M., Ahmed, A., Siner, A., Tien, W.I., Woon, L.C., Singh, B., Krishna, S. & Cox-Singh, J. (2012) Laboratory markers of disease severity in Plasmodium knowlesi infection: a case control study. Malaria Journal, 11:363.
  2. Fatih, F.A., Siner, A., Ahmed, A., Woon, L.C., Craig, A., Singh, B., Krishna, S. & Cox-Singh, J. (2012) Cytoadherence and virulence – the case of Plasmodium knowlesi malaria. Malaria Journal, 11, 33.
  3. Sermwittayawong, N., Singh, B., Nishibuchi, M., Swangjaroen, N. & Vuddhakul, V. (2012) Human Plasmodium knowlesi infection in Ranong province, south-western border of Thailand. Malaria Journal, 11, 36.
  1. Khim, N, Siv, S., Kim, S., Mueller, T., Fleischmann, E., Singh, B., Divis, P.C.S., Steenkeste, N., Duval, L., Bouchier, C., Duong, S., Ariey, F., Didier Ménard, D. (2011) Plasmodium knowlesi infection in humans, Cambodia, 2007-2010. Emerging Infectious Diseases 17(10). 1900-1902.
  2. Cox-Singh, J., Singh, B., Daneshvar, C., Planche, T., Parker-Williams, J. & Krishna, S. (2011) Anti-inflammatory cytokines predominate in acute human Plasmodium knowlesi infections. PLoS ONE, 6(6): e20541.
  3. Lee, K-S., Divis, P.C.S., Zakaria, S.K., Matusop, A., Julin, R.A., Cox-Singh, J., Conway, D.J. & Singh, B. (2011)Plasmodium knowlesi: Reservoir hosts and tracking the emergence in macaques and humans. PLoS Pathogens, 7(4): e1002015.
  4. Wong, P.S.J., Tan, C.H., Lee, V., Li, M.Z.I., Lee, K.S., Lee, P.J., Singh, B. & Ng, L.C. (2011) Molecular epidemiological investigation of Plasmodium knowlesi in humans and macaques in Singapore. Vector-Borne and Zoonotic Diseases 11, 131-135.
  1. Divis, P.C.S., Shokoples, S.E., Singh, B. & Yanow, S.K. (2010) A TaqMan real-time PCR assay for the detection and quantitation of Plasmodium knowlesi. Malaria Journal, 9, 344.
  2. Singh, B. & Daneshvar, C. (2010) Plasmodium knowlesi malaria in Malaysia. Medical Journal of Malaysia, 65, 224-230.
  3. Daneshvar, C., Davis, T.M.E, Cox-Singh, J., Rafa'ee, M.Z., Zakaria, S.K., Divis, P.C.S. & Singh, B. (2010) Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesiinfections. Malaria Journal, 9, 238.
  4. Cox-Singh, J., Singh, B. & Krishna, S. (2010) Plasmodium knowlesi: the fifth human malaria. In: Emerging Infections 9, Ed.: W.M. Sheld, M.L. Grayson & J.M. Hughes, ASM Press, Washington DC, USA; pp. 261-271.
  5. Cox-Singh, J., Hiu, J., Lucas, S.B., Divis, P.C., Zulkarnean, M., Chandran, P., Wong, K.T., Adem, P., Zaki, S.R., Singh, B. & Krishna, S. (2010) Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings.Malaria Journal, 9, 10.
  6. Ahouidi, A.D., Bei, A.K., Neafsey, D.E., Sarr, O., Volkman, S., Milner, D., Cox-Singh, J., Ferreira, M.U., Ndir, O., Premji, Z., Mboup, S., Duraisingh, M.T. (2010) Population genetic analysis of large sequence polymorphisms in Plasmodium knowlesi blood-stage antigens. Infection, Genetics & Evolution, 10, 200-206.
  1. Daneshvar, C., Davis, T.M.E., Cox-Singh, J., Rafa'ee, M.Z., Zakaria, S.K., Divis, P.C.S. & Singh, B. (2009) Clinical and laboratory features of human Plasmodium knowlesii infections. Clinical Infectious Diseases, 49, 852-8
  2. Singh, B. & Divis, P.C.S. (2009) Orangutans not infected with Plasmodium vivax or P. cynomolgi, Indonesia. Emerging Infectious Diseases, 15, 1657-1658.
  3. Lee, K-S., Cox-singh, J., Brooke, G., Matusop, A. & Singh, B. (2009) Palsmodium knowlesi from archival blood films: further evidence that human infections are widely distributed and not newly emergent in Malaysian Borneo.International Journal for Parasitology, 39, 1125-1128.
  4. Myers, W.P., Myers, A.P., Cox-Singh, J., Lau, H.C., Mokui, B. & Malley, R. (2009) Micro-geographic risk factors for malaria infection, Malaria Journal, 8, 27.
  5. Lee, K-S., Cox-Singh, J. & Singh, B. (2009) Morphological features and differential counts of Plasmodium knowlesiparasites in naturally acquired human infections. Malaria Journal, 8, 73.
  1. Cox-Singh, J., Davis, T.M.E., Lee, K.S., Shamsul S.S.G., Matusop, A., Ratnam, S., Rahman, H.A., Conway, D.J. & Singh, B. (2008) Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening. Clinical Infectious Diseases, 46, 165-171.
  2. Cox-Singh, J & Singh, B. (2008) Knowlesi malaria: newly emergent and of public health importance? Trends in Parasitology, 24, 406-410.
  3. Tan, C.H., Vythilingam, V., Chan, S.T., Matusop, M. & Singh, B. (2008) Bionomics of Anopheles latens in Kapit, Sarawak, Malaysian Borneo in relation to the transmission of zoonotic simian malaria parasite Plasmodium knowlesi. Malaria Journal, 7, 52.
  4. Luchavez, J., Espino, F.E., Curameng, P., Espina, R., Bell, D., Chiodini, P.L., Nolder, D., Sutherland, C.J., Lee, K-S. & Singh, B. (2008) Human infections with Plasmodium knowlesi, the Philippines. Emerging Infectious Diseases, 14, 811-813.
  1. Vythilingam, I., Tan, C.H., Asmad M., Chan, S.T., Lee K.S. & Singh B. (2006) Natural transmission of Plasmodium knowlesi to humans by Anopheles latens in Sarawak, Malaysia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 100, 1087-1088.
  1. Anthony, T.G., Conway, D.J., Cox-Singh, J., Shamsul, S.S.G., Matusop, A., Ratnam, S. & Singh, B. (2005) Fragmented population structure of Plasmodium falciparum in a region of declining endemicity. Journal of Infectious Diseases, 191, 1558-1564
  1. Singh, B., Lee, K.S., Matusop, A., Radhakrishnan, A., Shamsul, S.S.G., Cox-Singh, J., Thomas, A.W. & Conway, D. (2004) A large focus of naturally acquired Plasmodium knowlesi infections in human beings. The Lancet, 363, 1017-1024.
  1. Cox-Singh, J., Lu, H.Y., Davis, T.M.E., Ilett, K.F., Hackett, L.P., Matusop, A. & Singh, B. (2003) Application of a multi-faceted approach for the assessment of treatment response in falciparum malaria: a study from Malaysian Borneo. International Journal for Parasitology, 33, 1545-1552.
  1. Wolfe, N.D., Karesh, W.B., Kilbourn, A.M., Cox-Singh, J., Bosi, E.J., Rahman, H.A., Singh, B., Andau, M. & Spielman, A. (2002) The impact of ecological changes on the prevalence of malaria among orangutans. Vector Borne and Zoonotic Diseases. 2, 97-103.
  1. Conway, D.J., Machado, R., Singh, B., Dessert, P., Mikes, Z. S., Povoa, M., Oduola, A.M.J. & Roper, C. (2001) Extreme geographical fixation of variation in the Plasmodium falciparum gamete surface protein gene Pfs48/45 compared with microsatellite loci. Molecular and Biochemical Parasitology. 115, 145-156.
  2. Davis, T.M.E., Singh, B. & Sheridan, G. (2001) A case of parasitic procrastination: Late-presenting ovale malaria and schistosomiasis. Medical Journal of Australia. 175, 146-148.
  3. Menon, B.S., Abdullah, M.S., Mahamud, F., Morgan, U.M., Malik, A.S., Choo, K.E. & Singh, B. (2001) Low prevalence of Cryptosporidium parvum in hospitalised children in Kota Bharu, Malaysia. Southeast Asian Journal of Tropical Medicine and Public Health. 32, 319-322.
  4. Singh, B. & Cox-Singh, J. (2001) Parasites that cause problems in Malaysia: soil-transmitted helminths and malaria parasites. Trends in Parasitology. 17, 597-600.
  1. Ravichandran, M., Doolan, D.L., Cox-Singh, J., Hoffman, S.L. & Singh, B. (2000) HLA degenerate T-cell epitopes from Plasmodium falciparum liver stage-specific antigen-1 (LSA-1) are highly conserved in isolates from geographically distinct areas. Parasite Immunology, 22, 469-473.
  2. Conway, D.J., Fanello, C., Lloyd, J.M., Al-Joubori, B.M.A-S. Baloch, A.H., Somanath, S.D., Roper, C., Oduola A.M.J., Mulder, B., Povoa, M.M., Singh, B. & Thomas A.W. (2000) Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA. Molecular and Biochemical Parasitology, 111, 137-145
  3. Cox-Singh, J., Pomrehn, A.S., Wolfe, N.D., Rahman, H.A., Lu, H.Y. & Singh, B. (2000) Sensitivity of the nested PCR assay for Brugia malayi and the significance of ‘free’ DNA in PCR-based assays. International Journal for Parasitology, 30, 1177-1179
  4. Cox-Singh, J., Zakaria, R., Abdullah, M.S., Rahman, H.A., Nagappan, S. & Singh, B. (2000) Differences in dihydrofolate reductase but not dihydropteorate synthase alleles in Plasmodium falciparum isolates from geographically distinct areas in Malaysia. American Journal of Tropical Medicine and Hygiene, 64, 28-31
  1. Singh, B., Bobogare, A., Cox-Singh, J., Snounou, G., Abdullah M.S. & Rahman, H.A. (1999) A genus and species-specific nested polymerase chain reaction malaria detection assay for epidemiological studies. American Journal of Tropical Medicine and Hygiene, 60, 687-692
  2. Menon, B., Abdullah, M.S., Mahamud, F. & Singh, B. (1999) Intestinal parasites in Malaysian children with cancer. Journal of Tropical Paediatrics, 45, 241-242.
  3. Vythilingam, I., Nitiavathy, K., Yi, P., Bakotee, B., Hugo, B., Singh, B., Writz, R.A. & Palmer, K. (1999) A highly sensitive, nested polymerase chain reaction based method using simple DNA extraction to detect malaria sporozoites in mosquitoes. Southeast Asian Journal of Tropical Medicine and Public Health, 30, 631-635.
  4. Cox-Singh, J., Pomrehn, A., Rahman, H.A., Zakaria, R., Miller, A.O., & Singh, B. (1999) Simple blood-spot sampling with nested polymerase chain reaction detection for epidemiology studies on Brugia malayi. International Journal for Parasitology, 29, 717-721.